While it helps Many individuals, this medication provides a risk for abuse and could in some cases trigger dependancy. This danger might be better In case you have a compound use ailment (such as overuse of or addiction to medications/Liquor).
Carcinogenicity, mutagenicity, and fertility reports have not been carried out with Promethazine with Codeine Oral Alternative; having said that, revealed data is readily available for the person active elements.
The consequences of concomitant use or discontinuation of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with codeine are intricate, requiring cautious consideration of the effects to the mother or father drug, codeine, and the Lively metabolite, morphine.
Discontinuation of a concomitantly utilised cytochrome P450 2D6 inhibitor may perhaps lead to a lower in codeine plasma concentration and a rise in Energetic metabolite morphine plasma focus which could raise or prolong adverse reactions and will bring about possibly deadly respiratory despair.
Not less than one particular death was noted in a very nursing infant who was exposed to substantial levels of morphine in breast milk since the mom was an ultra-swift metabolizer of codeine.
Just before getting this medication, explain to your doctor or pharmacist For anyone who is allergic to promethazine or to dextromethorphan; or to any other phenothiazines (for example prochlorperazine); or Should you have some other allergic reactions.
Drug interactions may possibly alter how your prescription drugs perform or enhance your risk for serious Unintended effects. This document doesn't incorporate all probable drug interactions.
It should not be used to relieve suffering after surgical procedure to eliminate tonsils or adenoids in any youngsters. Serious respiratory problems and deaths have already been described in some youngsters who received codeine right after tonsil or adenoid surgical procedure.
While sizeable heterogeneity exists relating to CYP2D6 enzyme capability within all ethnicities, Hispanic and White individuals show the best CYP2D6 "ultrafast metabolizer" operation.[21]
Imaging might be used to support Assess the extent of ingestion (ie, suicide makes an attempt involving ingestion of whole tablet bottles)
Though specified medicines should not be utilised alongside one another in any respect, in other scenarios two different medicines could be utilised collectively regardless of whether an interaction might take place. In these scenarios, your doctor should want to change the dose, or other safety measures could possibly be important.
If a nursing mom is definitely an extremely-swift metabolizer of codeine, it could lead to some morphine overdose from the nursing baby and induce extremely severe Uncomfortable side effects.
For anyone who is using promethazine liquid, do not use a household spoon to evaluate your dose. Utilize the measuring spoon or cup that arrived Promethazine codeine syrup with the medication or use a spoon built especially for measuring medication.
Promethazine with Codeine Oral Option just isn't suggested for use in pregnant Ladies. Prolonged use of Promethazine with Codeine Oral Answer all through pregnancy may end up in withdrawal during the neonate. Neonatal opioid withdrawal syndrome, contrary to opioid withdrawal syndrome in Grownups, may be everyday living-threatening Otherwise identified and addressed, and requires administration As outlined by protocols designed by neonatology experts.